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01-16-2005,01:33 PM#1Member Join Date Nov 2004Location da city that doesn’t sleepPosts 34 question about recent bust ?someone emailed me stating there have been a lot of bust of MX sources. I haven’t heard much in reference to this matter on the board. Is there anyone who can elaborate on this ? they said becareful 2 main sources were nabbed and a few CD’s were performed… 01-16-2005,02:21 PM#2 Join Date Jan 2004Location NJPosts 211 Did you find this post helpful? | look in the “scammer” and “way it is” forum. youll find the answers you are looking for. tons of stuff on the outlaw board as well. 01-16-2005,04:57 PM#3Member Join Date Nov 2004Location da city that doesn’t sleepPosts 34 Did you find this post helpful? | thanks bro 01-16-2005,05:50 PM#4Senior Member Join Date Feb 2003Location “IN A PLACE YOU WANT TO BE”Posts 807 Did you find this post helpful? | Originally posted by bigsport look in the “scammer” and “way it is” forum. youll find the answers you are looking for. tons of stuff on the outlaw board as well. JUST THE ANSWER I WAS GOING TO GIVE, RESEARCH IT BROTHER. NO PROBLEM IN ASKING THOUGH…PEACE. PL 01-16-2005,06:01 PM#5Member Join Date Nov 2004Location da city that doesn’t sleepPosts 34 Did you find this post helpful? | thanks again bro i just want to bring it to the attention indirectly to those who dont know and make sure everyone is safe. + Reply to ThreadQuick NavigationSteroid TalkTopSite AreasSettingsPrivate MessagesSubscriptionsWho’s OnlineSearch ForumsForums HomeForumsBOARD NEWSMessages from StaffMessages to Sam (Web Tech)OldIntroductionsFeedbackHelp Donate to ABAB Member 2 AB Staff (Protected)AB SponsorsBNC SupplementsANABOLIC SECTIONSteroid TalkInformation StickiesNewbie CornerInjury and Infection DiscussionLaboratory DIY DiscussionUGL DISCUSSION & PICTURE SECTIONUnderground DiscussionFake AAS PicturesMex and Euro GearSteroid Profiles and Pictures (HG & UG)Steroids: Human Grade PicturesSteroids: Underground PicturesHEALTH & FITNESSThe ‘Natural’ BodyBuilderNutrition for PowerliftersPsychology & Mental HealthTraining HelpDiet and SupplementsStrength TrainingPowerliftingHGH & PEPTIDES DISCUSSIONHGH & IGF DiscussionFEMALE FORUMArticlesFemale Health and FitnessFemale Health & Fitness Picture GalleryRESULTS!Members’ PicturesMember ResultsPro-BodyBuilders**AB CLASSIFIEDS**AB Buy and Sel

and other scrapes and bruises. he was getting gas looked away for a second, dude jumps in and takes his truck with him hangin

and other scrapes and bruises. he was getting gas looked away for a second, dude jumps in and takes his truck with him hanging on. about 40-60 mph he let go. 08-19-2009,04:52 AM#18 Join Date Mar 2005Posts 644 Did you find this post helpful? | Originally Posted by wallydjust curious, what difference does it make if you know who carries and who doesnt? there are certain things to look for that will tip you off as to who is and who isnt if it really matters. the first paragraph you posted up is totally correct too btw. if johnny tries to run me down while taking my car or a family member is in the car so it becomes a hostage situation i believe its game on my friend. i am not wanting to go back to the wildwest by any means, but if they will make it legal for me to protect my family legally i will.Bro, I believe in our constitutional rights to bear arms. My perspective is based on my life experience and my demographics. I’ve seen too many innocent people get hurt as a result of firearms. Just imagine what can happen when you discharge a semi-automatic weapon in a populated area or what can happen when a high caliber bullet goes through stucco, wallboard, car windows or a store front. I agree that one should be allowed to bear arms to protect thier families. I just want to see them so I can protect mine. Then again it would be nice if the bad guys showed their concealed weapons also, LOL. Just one man’s “urban perspective.” Getting back on topic, LOL, good luck finding a holster or vest bro — don’t forget the matching shoes :059: 09-12-2009,06:53 PM#19 Join Date Jul 2004Location hootervillePosts 1,214 Did you find this post helpful? | i just got the holster in today. this thing is more than i expected!!! holds weapon very snug, has a couple of different adjustments on it, just all around VERY IMPRESSED!!! if you are looking check this guy out; dm bullard leather mfg. i am usually leary of buying anything like this on line that i havent been able to physically see, but man this thing is NICE! 09-13-2009,08:21 AM#20 Join Date Feb 2003Posts 606 Did you find this post helpful? | This is the way to go: /product/Spo…,1146,1410.htm + Reply to ThreadQuick NavigationGeneral DiscussionTopSite AreasSettingsPrivate MessagesSubscriptionsWho’s OnlineSearch ForumsForums HomeForumsBOARD NEWSMessages from StaffMessages to Sam (Web Tech)OldIntroductionsFeedbackHelp Donate to ABAB Member 2 AB Staff (Protected)AB SponsorsBNC SupplementsANABOLIC SECTIONSteroid TalkInformation StickiesNewbie CornerInjury and Infection DiscussionLaboratory DIY DiscussionUGL DISCUSSION & PICTURE SECTIONUnderground DiscussionFake AAS PicturesMex and Euro GearSteroid Profiles and Pictures (HG & UG)Steroids: Human Grade PicturesSteroids: Underground PicturesHEALTH & FITNESSThe ‘Natural’ BodyBuilderNutrition for PowerliftersPsychology & Mental HealthTraining HelpDiet and SupplementsStrength TrainingPowerliftingHGH & PEPTIDES DISCUSSIONHGH & IGF DiscussionFEMALE FORUMArticlesFemale Health an

here king for a day, you guys would holster that bad boy where it would be visible to everyone. I’m the nervous type. JMHO, no

here king for a day, you guys would holster that bad boy where it would be visible to everyone. I’m the nervous type. JMHO, no offense brother.if anyone shoots a person just because they have a ccw permit and are totally legal they better plan on being handcuffed and hauled in at gun point. you will go to jail and the authorities will sort it out later.just curious, what difference does it make if you know who carries and who doesnt? there are certain things to look for that will tip you off as to who is and who isnt if it really matters. the first paragraph you posted up is totally correct too btw. if johnny tries to run me down while taking my car or a family member is in the car so it becomes a hostage situation i believe its game on my friend. i am not wanting to go back to the wildwest by any means, but if they will make it legal for me to protect my family legally i will. 08-18-2009,05:52 PM#16Senior Member Join Date Feb 2003Location USAPosts 522 Did you find this post helpful? | Originally Posted by Habanero”In some states liability is present where the licensee brandishes the weapon, threatens use, or exacerbates a volatile situation, or when the licensee is carrying while intoxicated. While state laws vary, generally use of deadly force must be a matter of last resort, when life or limb is endangered, when escape or retreat are foreclosed, and warnings are given but ignored”In the situation you described, If you blew away crack head johnny you would probably go to jail. I believe in the “right to bear arms” bro, I just don’t like the “conceal” part. Personally, I like to know who has a gun around me. If I where king for a day, you guys would holster that bad boy where it would be visible to everyone. I’m the nervous type. JMHO, no offense brother.My state justifies the use of deadly force when you are trying to protect yourself or another person from death or serious bodily harm, or trying to prevent a forcible felony, such as rape, robbery, burglary, or kidnapping. On the other hand, even if it was illegal to shoot crackhead Johnny, would you rather go to jail for saving your daughter, or would it be more responsible to let the police find her raped and murdered body in an alley somewhere? 08-18-2009,07:56 PM#17 Join Date Jul 2004Location hootervillePosts 1,214 Did you find this post helpful? | Originally Posted by deuce9595My state justifies the use of deadly force when you are trying to protect yourself or another person from death or serious bodily harm, or trying to prevent a forcible felony, such as rape, robbery, burglary, or kidnapping. On the other hand, even if it was illegal to shoot crackhead Johnny, would you rather go to jail for saving your daughter, or would it be more responsible to let the police find her raped and murdered body in an alley somewhere?ditto….. just watch the news if you think this shit doesnt happen. an acquintance is laying in the hospital right now with a broken leg, gashed up head, a foot that was run over by his own vehicle

comfortable with. The vest is awesome. Once you get accustomed to the extra weight you can’t even tell it’s in there. I often p

comfortable with. The vest is awesome. Once you get accustomed to the extra weight you can’t even tell it’s in there. I often pat the area down just to prove to myself that it’s still there.LOL I’m guilty of the same bro! My little 340PD airlite is so light (11oz empty) that I often forget! The vest I posted the link to carries much like a shoulder holster. Also check out coronadoleather.com, they make the first vests twin in leather, I have the buffalo hide that I wear when riding my chopper and it’s a damn nice vest too. Buy quality guys and you won’t have to buy twice! The nylon cheapo I was talkin about earlier wore out in a year or so, but it was only 12 bucks and does the job when I’m in a t-shirt and shorts. 08-17-2009,06:11 AM#13Senior Member Join Date Feb 2003Location USAPosts 522 Did you find this post helpful? | Very cool. If anyone else is interested in vests you can check the link below. They are not too, too expensive, I have one of these and am very pleased with the quality./Leather_…_Vest_s/18.htm 08-18-2009,05:51 AM#14 Join Date Mar 2005Posts 644 Did you find this post helpful? | Originally Posted by wallydthanks but if crack head johnny wants my car with my daughter in the backseat just because i made a wrong turn guess what, i plan on living to see her smile another day! its totally legal, i am following all laws, and i just want to protect my family from the people who do it illegally. not bashing your opinion but it’s pretty one sided.ThumbDown”In some states liability is present where the licensee brandishes the weapon, threatens use, or exacerbates a volatile situation, or when the licensee is carrying while intoxicated. While state laws vary, generally use of deadly force must be a matter of last resort, when life or limb is endangered, when escape or retreat are foreclosed, and warnings are given but ignored”In the situation you described, If you blew away crack head johnny you would probably go to jail. I believe in the “right to bear arms” bro, I just don’t like the “conceal” part. Personally, I like to know who has a gun around me. If I where king for a day, you guys would holster that bad boy where it would be visible to everyone. I’m the nervous type. JMHO, no offense brother. 08-18-2009,03:50 PM#15 Join Date Jul 2004Location hootervillePosts 1,214 Did you find this post helpful? | Originally Posted by Habanero”In some states liability is present where the licensee brandishes the weapon, threatens use, or exacerbates a volatile situation, or when the licensee is carrying while intoxicated. While state laws vary, generally use of deadly force must be a matter of last resort, when life or limb is endangered, when escape or retreat are foreclosed, and warnings are given but ignored”In the situation you described, If you blew away crack head johnny you would probably go to jail. I believe in the “right to bear arms” bro, I just don’t like the “conceal” part. Personally, I like to know who has a gun around me. If I w

ticlesFemale Health and FitnessFemale Health & Fitness Picture GalleryRESULTS!Members’ PicturesMember ResultsPro-BodyBuilde

05-17-2006,10:25 PM#1Guest wowAwesome stuff in those stickies guys… thanks 05-18-2006,05:46 PM#2Guest Did you find this post helpful? | Good info I collected over time. 05-24-2006,02:55 PM#3Banned Join Date Aug 2005Posts 15 Did you find this post helpful? | thats one stop shopping for information… i was army infantry for 3 years and ive been a fireman for 5 1/2 years… with those recipes, instructions, directions even an idiot like me can make their own gear…LOL + Reply to ThreadQuick NavigationLaboratory DIY DiscussionTopSite AreasSettingsPrivate MessagesSubscriptionsWho’s OnlineSearch ForumsForums HomeForumsBOARD NEWSMessages from StaffMessages to Sam (Web Tech)OldIntroductionsFeedbackHelp Donate to ABAB Member 2 AB Staff (Protected)AB SponsorsBNC SupplementsANABOLIC SECTIONSteroid TalkInformation StickiesNewbie CornerInjury and Infection DiscussionLaboratory DIY DiscussionUGL DISCUSSION & PICTURE SECTIONUnderground DiscussionFake AAS PicturesMex and Euro GearSteroid Profiles and Pictures (HG & UG)Steroids: Human Grade PicturesSteroids: Underground PicturesHEALTH & FITNESSThe ‘Natural’ BodyBuilderNutrition for PowerliftersPsychology & Mental HealthTraining HelpDiet and SupplementsStrength TrainingPowerliftingHGH & PEPTIDES DISCUSSIONHGH & IGF DiscussionFEMALE FORUMArticlesFemale Health and FitnessFemale Health & Fitness Picture GalleryRESULTS!Members’ PicturesMember ResultsPro-BodyBuilders**AB CLASSIFIEDS**AB Buy and Sell – INTERNATIONAL -Magnum PharmaceuticalsAlpha Pharmaceuticals (ALP)Supplier FeedbackScammersBustsENTERTAINMENT SECTIONMusicAdult LinksAdult TalkPixs and MoviesWhat you got!OTHERGeneral Discussion*NEW* Conspiracy ForumFlame ForumGeneral SalesTanning DiscussionPolitics, Politics , PoliticsSports ChatPoll ForumLegal Articles/Legal DiscussionHigh Tech InfoFriends of ABFriend LinksWorldClassBodybuilding.comvBulletin MessageCancel Changes conceal carry holster – Page 2
08-14-2009,03:56 PM#11 Join Date Jul 2004Location hootervillePosts 1,214 Did you find this post helpful? | nonya the gunshow is a great idea, i didnt think of that. :moron: thanks duece, havent checked any vest out yet. 08-14-2009,04:41 PM#12Senior Member Join Date Jan 2006Posts 255 Did you find this post helpful? | Originally Posted by deuce9595I have my carry permit too. I wear a leather biker vest with gun pockets. I’ve tried on a few holsters but never found one that I was

tures (HG & UG)Steroids: Human Grade PicturesSteroids: Underground PicturesHEALTH & FITNESSThe ‘Natural’ BodyBuilderNut

09-05-2003,03:41 PM#1Guest b-12?Hey bros i have a quick question, i got 100ml of b12, but as we all know drawing out with a pin and using that same pin just isnt the most painless thing in the world, so i was thinking of pre filling my pinz, and using them as needed….would this be ok with b-12. and if its cool, should i keep them in thr fridge, or anything like that?…thanks brothas….Latin 09-05-2003,05:24 PM#2 Join Date Feb 2003Location HerePosts 1,994 Did you find this post helpful? | Yeah, you could prefill your syringes, but why don’t you just change pins before injecting? That will be the best way to ensure sterility IMO. If you’re set in prefilling, then make sure you wrap them up (foil/plastic wrap) and I guess putting them in the fridge would inhibit any bacterial growth from potential contamination. 09-05-2003,06:04 PM#3Guest Did you find this post helpful? | I always use a 18 guage to draw and leave it in the top of the vial to be used to draw again the next time. Never had a problem with infections ever. 09-06-2003,11:00 PM#4Guest Did you find this post helpful? | bump 09-08-2003,05:07 AM#5 Join Date Feb 2003Location Big Bad BlvdPosts 4,144 Did you find this post helpful? | I always use a 20g or so to draw and then switch to a 23g to inj. + Reply to ThreadQuick NavigationSteroid TalkTopSite AreasSettingsPrivate MessagesSubscriptionsWho’s OnlineSearch ForumsForums HomeForumsBOARD NEWSMessages from StaffMessages to Sam (Web Tech)OldIntroductionsFeedbackHelp Donate to ABAB Member 2 AB Staff (Protected)AB SponsorsBNC SupplementsANABOLIC SECTIONSteroid TalkInformation StickiesNewbie CornerInjury and Infection DiscussionLaboratory DIY DiscussionUGL DISCUSSION & PICTURE SECTIONUnderground DiscussionFake AAS PicturesMex and Euro GearSteroid Profiles and Pictures (HG & UG)Steroids: Human Grade PicturesSteroids: Underground PicturesHEALTH & FITNESSThe ‘Natural’ BodyBuilderNutrition for PowerliftersPsychology & Mental HealthTraining HelpDiet and SupplementsStrength TrainingPowerliftingHGH & PEPTIDES DISCUSSIONHGH & IGF DiscussionFEMALE FORUMAr

on for PowerliftersPsychology & Mental HealthTraining HelpDiet and SupplementsStrength TrainingPowerliftingHGH & PEPTID

05-09-2006,05:08 PM#1Guest test and eqhow it going fellasi started out running test e @ 300 wkly and all was good and so was hank . then 5 weeks into this cycle i added eq @ 600 wkly and continued test @300 and bye bye sex drive , i have run this cycle before and had a huge sex drive and now not so much. any ideas why ? 05-09-2006,05:11 PM#2 Join Date May 2003Location Armpit of the NationPosts 616 Did you find this post helpful? | Up your test to 600 or above. 05-09-2006,05:47 PM#3Guest Did you find this post helpful? | same gear from same source? possible it is underdosed bro, taking any arimidex? 05-09-2006,06:03 PM#4Guest Did you find this post helpful? | MDC would you recommend Proviron for this issue… 05-09-2006,08:17 PM#5Member Join Date Mar 2006Posts 62 Did you find this post helpful? | HeyI always keep my Test higher than my EQ or what ever it may be. 05-09-2006,09:20 PM#6Guest Did you find this post helpful? | mdc , yes 1mg every mon wed fri . im gyno prone and even just 200 of test sets it off , im not a big fan of test but i know i need it with cycles , so i choose to run it low with aas that have low or no conversion. usp test msl eq 05-09-2006,09:59 PM#7Senior Member Join Date Jun 2004Posts 278 Did you find this post helpful? | Why is the EQ killing his sex drive? It shouldnt do that, correct? 05-09-2006,10:22 PM#8 Join Date May 2004Posts 499 Did you find this post helpful? | I never had any problems with Eq like that, if you dont want to up the test, get some Tribbulus or something of that nature and maybe some cialis. 05-09-2006,11:29 PM#9Senior Member Join Date Jun 2004Posts 278 Did you find this post helpful? | I still dont understand why he has to up the test. EQ is androgenic + Reply to ThreadQuick NavigationSteroid TalkTopSite AreasSettingsPrivate MessagesSubscriptionsWho’s OnlineSearch ForumsForums HomeForumsBOARD NEWSMessages from StaffMessages to Sam (Web Tech)OldIntroductionsFeedbackHelp Donate to ABAB Member 2 AB Staff (Protected)AB SponsorsBNC SupplementsANABOLIC SECTIONSteroid TalkInformation StickiesNewbie CornerInjury and Infection DiscussionLaboratory DIY DiscussionUGL DISCUSSION & PICTURE SECTIONUnderground DiscussionFake AAS PicturesMex and Euro GearSteroid Profiles and Pic

nd an experimental agent, GC-1, has been developed that selectively binds the TRbeta receptor, with minimal effects on the hear

nd an experimental agent, GC-1, has been developed that selectively binds the TRbeta receptor, with minimal effects on the heart (30). The distribution and actions of TRalpha and TRbeta throughout the body are not yet well characterized. However should it turn out that TRalpha is specific to the heart, then drugs like GC-1 may turn out to be effective fat burning agents with a much safer profile that T3 or T4.One alleged “futuristic” agent that is here now is T2, or 3,5-Di-iodo-L-thyronine, the T3 metabolite discussed above. Unfortunately, this product does not live up to its hype. It has been claimed to be as or more effective that T3 for fat burning with minimal suppression of endogenous thyroid production. Regarding the relative effectiveness of T2 as a lipolytic agent, and its effect on TSH, this topic was thoroughly covered in a recent article by Bryan Haycock in Muscle Monthly:All of my research into this subject has led me to the same conclusion reached by Mr. Haycock. That is, T2 is only slightly less suppressive of TSH than is T3, and only packs a portion of the lipolytic punch of T3, with no ability to increase the expression of the UCPs, which is a major determinant of the action of thyroid hormone.SummaryWe have discussed a number of ways by which T3, and its active metabolite T2 act to increase resting energy expenditure. Also discussed were some drawbacks of T3 use, such as cardiac stress, as well as the potential loss of muscle mass. It is ironic that the latter may be of more concern to many bodybuilders that the other more serious potential impacts on health. Nevertheless, used moderately and for short periods (a couple of months or less) in people with no preexisting cardiovascular disease T3 has a relatively safe medical profile, compared to other lipolytic agents like DNP. Perhaps most importantly we have presented substantial evidence that even the long-term use of supraphysiological levels of T3 does not damage the thyroid gland.__________________ 06-14-2010,01:59 PM#7Member Join Date Jun 2010Posts 57 Did you find this post helpful? | Most everything I have read about T-3 says it will eat you up, so you need to do it along with an aas. I am about to start a t-3 clen stack as well, and plan to combine it with anavar to maintain muscle mass. I stopped taking my ECA stack last week as I also read it uses the same receptor sites as the clen. + Reply to ThreadQuick NavigationSteroid TalkTopSite AreasSettingsPrivate MessagesSubscriptionsWho’s OnlineSearch ForumsForums HomeForumsBOARD NEWSMessages from StaffMessages to Sam (Web Tech)OldIntroductionsFeedbackHelp Donate to ABAB Member 2 AB Staff (Protected)AB SponsorsBNC SupplementsANABOLIC SECTIONSteroid TalkInformation StickiesNewbie CornerInjury and Infection DiscussionLaboratory DIY DiscussionUGL DISCUSSION & PICTURE SECTIONUnderground DiscussionFake AAS PicturesMex and Euro GearSteroid Profiles and Pictures (HG & UG)Steroids: Human Grade PicturesSteroids: Underground PicturesHEALTH & FITNESSThe ‘Natural’ BodyBuilderNutriti

ceptor described above, they initiate a signaling cascade mediated by the so called “second messenger” cyclic AMP (cAMP). cAMP

ceptor described above, they initiate a signaling cascade mediated by the so called “second messenger” cyclic AMP (cAMP). cAMP in turn acts on other cellular enzymes to initiate and maintain lipolysis. The original signal is terminated when cAMP is degraded by the enzyme phosphodiesterase. Clearly, maintaining elevated cAMP levels, by lowering phosphodiesterase concentrations with T3, will prolong lipolysis.As an aside, caffeine is thought to exert at least a portion of its lipolytic action by lowering phosphodiesterase in fat cells. Interestingly, Viagra and cialis are also phosphodiesterase inhibitors but their action seems to be limited to relaxing vascular smooth muscles.Increased Growth Hormone SecretionIn vitro, animal, and human studies have all demonstrated that T3 administration increases growth hormone production. (24)(25) Since GH is calorigenic aside from any increase in igf-1, elevated GH may contribute to some of the fat burning associated with T3 administration. This effect may obviate the need for the use of expensive recombinant HGH, as mentioned above.Decreased Insulin SecretionInsulin is well known as a lipogenic hormone. It promotes fat storage by facilitating the uptake of fatty acids by adipocytes, and reducing lipid oxidation in muscle tissue. Several studies have shown that thyroid hormone is associated with glucose intolerance resulting from decreased glucose stimulated insulin secretion (26).This defect in insulin secretion is believed to result from an increase in the rate of apoptosis (programmed cell death) of pancreatic beta cells as a direct effect of thyroid hormone excess.(27) This process is reversible, since when thyroid hormone is withdrawn the rate of beta cell replication increases until homeostasis returns. However, there are conflicting studies regarding the effects of T3 on insulin. For example, Dimitriadis et al (28) showed a decrease in glucose stimulated insulin secretion, consistent with (25), but an increase in basal insulin. They also observed increased insulin clearance, with a compensatory increase in basal insulin secretion.So if in fact the hyperthyroid state is associated with lower insulin levels, this could explain a portion of hyperthyroid stimulated lipolysis. The obvious downside here is that insulin is also an anabolic hormone. Basal insulin concentration is thought to limit the action of the ubiquitin-proteasome degradative pathway of muscle protein breakdown (29). Of course supplementing with insulin during T3 use would be counterproductive. However, as mentioned above, anabolic steroids inhibit ubiquitin-proteasome activity, so their use could counter any loss in muscle anabolism resulting from a drop insulin levels.The FutureAs mentioned at the beginning of this article, a major roadblock in the adoption of T3 by the medical community as an antiobesity agent is its deleterious effect on the heart. Recent research has identified two isoforms of the thyroid hormone receptor, TRalpha and TRbeta. The TRalpha-form may preferentially regulate the heart rate, a

tivate HSL. The upregulation of the beta 2 receptor due to T3 results in an increased ability of catecholamines to activate HSL

tivate HSL. The upregulation of the beta 2 receptor due to T3 results in an increased ability of catecholamines to activate HSL, leading to increased lipolysis.Bodybuilders often use drugs like clenbuterol, which bind to the beta 2 receptors and activate them in the same way as the body’s endogenous catecholamines. The use of clenbuterol along with T3 can produce an additive lipolytic effect: T3 increases the number of receptors, while clenbuterol binds to the receptors activating HSL and increasing lipolysis. Since clenbuterol itself downregulates the beta 2 receptor, most bodybuilders use clenbuterol in a two week on/ two week off cycle, the rationale being that this minimizes downregulation and allows receptor recovery. Another option is to use the antihistamine Ketotifen concurrently with the clenbuterol. Studies have shown that Ketotifen attenuates the beta 2 receptor downregulation caused by clenbuterol (15). Moreover, research in AIDS patients has shown that Ketotifen blocks the production of the proinflammatory and catabolic cytokine TNF-alpha (16). This may be of relevance to bodybuilders since there is evidence showing TNF lowers both testosterone and IGF-1 levels quite significantly (17) (18), while strenuous exercise elevates TNF levels. (19)Besides increasing beta 2 receptor density in adipose tissue, T3 upregulates this receptor in human skeletal muscle (12). This has some very intriguing if somewhat speculative implications for the combined use of clenbuterol and T3. Animal studies have shown that catecholamines, particularly clenbuterol, inhibit Ca++ dependent skeletal muscle proteolysis (20). Like the lysosomal and ubiquitin-proteasome pathways discussed above, Ca++ regulated proteolysis is yet another way for the body to degrade muscle protein. Again the implications are enticing: Increased beta 2 receptor density from T3 use, coupled with the beta 2 agonist clenbuterol, could slow this pathway of muscle catabolism.Another adrenergic receptor important to lipolysis is the alpha 2 receptor, which impedes fat mobilization by counteracting the effects of the beta 2 receptor. There are some conflicting studies about the effects of T3 on the alpha 2 receptor, with studies showing either a downregulation (21) or no effect (22). If T3 does in fact downregulate alpha 2 receptors, this would further aid lipolysis.Studies in rats have shown that inducing hyperthyroidism increases the lipolytic beta 3 receptor density in white adipose tissue by 70% (23). Beta 3 receptors are abundant in human white adipose tissue as well, and if T3 administration has the same effect in humans, this could could contribute significantly to T3 induced fat loss. This might also argue for taking a currently available beta 3 agonist such as octopamine along with T3 and perhaps clenbuterol.Decreased Phosphodiesterase ExpressionIn hyperthyroid patients as well as in normal subjects given T3, levels of the enzyme phosphodiesterase are lowered in fat cells (20). When lipolytic hormones like epinephrine (adrenaline) bind to the beta 2 re